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The research report of the UNN biomedical team about the results of their studies on the mechanisms of accelerated ageing in patients with severe kidney pathology was named the best in the competition of young scientists at the VII Congress of the CIS Physiologists and the VII Congress of Biochemists of Russia. The event was held from 3 to 7 October 2022 in Sochi as part of the III United Science Forum.

"A total of 163 Nizhny Novgorod residents, including patients with terminal chronic kidney disease (CKD) and those on haemodialysis, participated in the study of accelerated ageing mechanisms. We determined the level of accelerated ageing factors in blood plasma, as well as the expression of the Klotho "longevity" gene," said Maria Vedunova, director of the UNN Institute of Biology and Biomedicine.

The scientists identified 18 indicators and atypical biomarkers that provoke accelerated ageing.

"Significant differences were found in the plasma levels of GDF15, FGF21, FGF23 factors in such patients compared to controls. Specific plasma biomarkers have been identified which, in combination with chronic inflammation, provoke accelerated ageing," Maria Vedunova added.

At present, UNN scientists are developing approaches to control these indicators, which will help to improve the quality of life of patients on haemodialysis. The research was supported by the grant of the Russian Government
“Digital Personalized Medicine for Healthy Ageing: Network Analysis of Big Multivariate Data to Find New Diagnostic, Predictive and Therapeutic Targets”