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uchyonye nngu i ngtu predlozhili novuyu metodiku izucheniya nejtrofilov

A team of researchers from Lobachevsky University and  Alekseev Technical University of Nizhny Novgorod has developed a new technique that makes it possible to observe and study neutrophil migration in three-dimensional space in real time. By using the proposed technique, the scientists found that neutrophils use different mechanisms of migration through the endothelium to reach the inflammation focus.

The technique developed by the scientists offers new insights into neutrophil migration and may lead to new discoveries in understanding the processes occurring during inflammation. This is an important step towards a more precise characterization of the mechanisms regulating neutrophil migration, which may contribute to the development of new methods for the treatment and prevention of inflammatory diseases.

"Inflammation is a normal protective reaction of the organism that accompanies various diseases. The essence of the research we are conducting is to study the individual elements of this process. We investigate how it can be influenced, and what specific features it has. Neutrophils play an important role in these processes, as they, due to their high mobility and phlogogenic potential, not only can localize and destroy pathogenic microorganisms, but also, on the contrary, can expand the zone of inflammation. Studying the morphology of these cells, chemical and physiological changes that occur in such cells, we better understand their special role in the development of the body's protective reactions," said Professor Svetlana Pleskova, Head of the Research Laboratory for Scanning Probe Microscopy at Lobachevsky University.

The innovative technique opens up new possibilities for studying neutrophil migration in real time. The data obtained will help to expand knowledge about the functioning of the immune system and the mechanisms that allow immune cells to reach the focus of inflammation during tissue damage or infections. The research project "Study of the processes of forward and reverse transendothelial migration of neutrophil granulocytes by scanning ion-conduction microscopy" was supported by a grant from the Russian Science Foundation, and the results were published in the journal Cells.